Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Tumor-associated macrophages (TAMs) are critical in promoting tumor progression and
therapeutic resistance. In adapting to metabolic changes in the tumor microenvironment …

Metastatic cancer cells dynamically adjust their shape to adhere, invade, migrate, and
expand to generate secondary tumors. Inherent to these processes is the constant assembly …

Breast cancer, the most frequent female malignancy, is often curable when detected at an
early stage. The treatment of metastatic breast cancer is more challenging and may be …

Antibody drug conjugates (ADCs) are novel drugs that exert specific cytotoxicity against
tumor cells. China approved T‐Dxd in May 2023, and their introduction has changed the …

HER2 is an established therapeutic target in breast, gastric, and gastroesophageal junction
carcinomas with HER2 overexpression or genomic alterations. The humanized monoclonal …

Background Previous studies have demonstrated that PANoptosis is strongly correlated with
cancer immunity and progression. This study aimed to develop a PANoptosis-related …

A TGF-β–dominant chemoresistant phenotype of hepatoblastoma... : Hepatology A TGF-β–dominant
chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children …

The extracellular matrix (ECM) is critical for drug resistance in colorectal cancer (CRC). The
abundant collagen within the ECM significantly influences tumor progression and matrix …

Background For patients with high grade serous carcinoma of the ovary (HGSC), survival
rates have remained static for the last half century. Despite the presence of tumor mutations …