H2‐producing microorganisms are a promising source of sustainable biohydrogen.
However, most H2‐producing microorganisms are anaerobes, which are difficult to cultivate …

Abstract This study employs Lagrangian Sensor Particles (LSPs) with a diameter of 40 mm
equipped with a pressure sensor to investigate cell lifelines in a 15,000 L stirred tank reactor …

The hydromechanical stress is a relevant parameter for mammalian cell cultivations,
especially regarding scale-up processes. It describes the mechanical forces exerted on cells …

Cultivating Chinese hamster ovary (CHO) cells in microtiter plates (MTPs) with time‐
resolved monitoring of the oxygen transfer rate (OTR) is highly desirable to provide process …

The Ames test is one of the most applied tools in mutagenicity testing of chemicals ever
since its introduction by Ames et al. in the 1970s. Its principle is based on histidine …

Background Determining the cytotoxicity of test substances is essential for the safety
assessment of chemicals. To quantify the cytotoxicity, dose–response curves are determined …

Significant progress has been achieved in large-scale mammalian cell culture technology
for biotherapeutics manufacturing over the past decades, necessitating the Process …

Cell line generation of mammalian cells is a time‐consuming and labor‐intensive process,
especially because of challenges in clone selection after transfection. Antibiotics are …

Cultivating microorganisms on solid agar media is a fundamental technique in microbiology
and other related disciplines. For the evaluation, most often, a subjective visual examination …

Recombinant proteins represent almost half of the top selling therapeutics—with over a
hundred billion dollars in global sales—and their efficacy and safety strongly depend on …