High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
Targeting cancer vulnerabilities with high-dose vitamin C
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
Vitamin C: the known and the unknown and Goldilocks
SJ Padayatty, M Levine - Oral diseases, 2016 - Wiley Online Library
Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations
and are often refractory to approved targeted therapies. We found that cultured human CRC …
and are often refractory to approved targeted therapies. We found that cultured human CRC …
Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …
Ascorbic acid: chemistry, biology and the treatment of cancer
J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis
AA Fowler, AA Syed, S Knowlson, R Sculthorpe… - Journal of translational …, 2014 - Springer
Background Parenterally administered ascorbic acid modulates sepsis-induced
inflammation and coagulation in experimental animal models. The objective of this …
inflammation and coagulation in experimental animal models. The objective of this …
Effect of high-dose ascorbic acid on vasopressor's requirement in septic shock
MH Zabet, M Mohammadi, M Ramezani… - Journal of research in …, 2016 - journals.lww.com
Objective: Effects of ascorbic acid on hemodynamic parameters of septic shock were
evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the …
evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the …
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy
Y Ma, J Chapman, M Levine, K Polireddy… - Science translational …, 2014 - science.org
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …
Ascorbic acid in cancer treatment: let the phoenix fly
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …