High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Targeting cancer vulnerabilities with high-dose vitamin C

B Ngo, JM Van Riper, LC Cantley, J Yun - Nature Reviews Cancer, 2019 - nature.com
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Vitamin C: the known and the unknown and Goldilocks

SJ Padayatty, M Levine - Oral diseases, 2016 - Wiley Online Library
Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier… - Science, 2015 - science.org
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations
and are often refractory to approved targeted therapies. We found that cultured human CRC …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

A Boretti, BK Banik - PharmaNutrition, 2020 - Elsevier
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …

Ascorbic acid: chemistry, biology and the treatment of cancer

J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

AA Fowler, AA Syed, S Knowlson, R Sculthorpe… - Journal of translational …, 2014 - Springer
Background Parenterally administered ascorbic acid modulates sepsis-induced
inflammation and coagulation in experimental animal models. The objective of this …

Effect of high-dose ascorbic acid on vasopressor's requirement in septic shock

MH Zabet, M Mohammadi, M Ramezani… - Journal of research in …, 2016 - journals.lww.com
Objective: Effects of ascorbic acid on hemodynamic parameters of septic shock were
evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the …

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy

Y Ma, J Chapman, M Levine, K Polireddy… - Science translational …, 2014 - science.org
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …

Ascorbic acid in cancer treatment: let the phoenix fly

N Shenoy, E Creagan, T Witzig, M Levine - Cancer cell, 2018 - cell.com
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …