Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare
Trauma-and disease-related skeletal defects and illnesses are plaguing millions of people
especially in an ageing globe. Recently, the convergence of additive manufacturing (AM) …
especially in an ageing globe. Recently, the convergence of additive manufacturing (AM) …
[HTML][HTML] Recent development in multizonal scaffolds for osteochondral regeneration
L Yu, S Cavelier, B Hannon, M Wei - Bioactive Materials, 2023 - Elsevier
Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …
[HTML][HTML] Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration
Y Wang, Y Chen, Y Wei - Biomaterials translational, 2022 - ncbi.nlm.nih.gov
Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …
A one‐stone‐two‐birds strategy for osteochondral regeneration based on a 3d printable biomimetic scaffold with kartogenin biochemical stimuli gradient
Osteochondral defect (OCD) regeneration remains challenging because of the hierarchy of
the native tissue including both the articular cartilage and the subchondral bone …
the native tissue including both the articular cartilage and the subchondral bone …
Injectable Bioadhesive Photocrosslinkable Hydrogels with Sustained Release of Kartogenin to Promote Chondrogenic Differentiation and Partial‐Thickness Cartilage …
Q Han, J He, L Bai, Y Huang, B Chen… - Advanced …, 2024 - Wiley Online Library
Partial‐thickness cartilage defect (PTCD) is a common and formidable clinical challenge
without effective therapeutic approaches. The inherent anti‐adhesive characteristics of the …
without effective therapeutic approaches. The inherent anti‐adhesive characteristics of the …
Transplantable stem cell nanobridge scaffolds for accelerating articular cartilage regeneration
S Park, JY Na, Y Gwon, W Kim, JY Kang, JK Seon… - Biomaterials, 2023 - Elsevier
Microfracture technique for treating articular cartilage defects usually has poor clinical
outcomes due to critical heterogeneity and extremely limited in quality. To improve the …
outcomes due to critical heterogeneity and extremely limited in quality. To improve the …
Preparation and characterization of biomimetic functional scaffold with gradient structure for osteochondral defect repair
L Chen, L Wei, X Su, L Qin, Z Xu, X Huang, H Chen… - Bioengineering, 2023 - mdpi.com
Osteochondral (OC) defects cannot adequately repair themselves due to their sophisticated
layered structure and lack of blood supply in cartilage. Although therapeutic interventions …
layered structure and lack of blood supply in cartilage. Although therapeutic interventions …
Regeneration of articular cartilage defects: Therapeutic strategies and perspectives
X Guo, L Xi, M Yu, Z Fan, W Wang… - Journal of Tissue …, 2023 - journals.sagepub.com
Articular cartilage (AC), a bone-to-bone protective device made of up to 80% water and
populated by only one cell type (ie chondrocyte), has limited capacity for regeneration and …
populated by only one cell type (ie chondrocyte), has limited capacity for regeneration and …
Glass, ceramic, polymeric, and composite scaffolds with multiscale porosity for bone tissue engineering
D Jeyachandran, M Cerruti - Advanced Engineering Materials, 2023 - Wiley Online Library
Porosity affects performance of scaffolds for bone tissue engineering both in vitro and in
vivo. Macropores (ie, pores with a diameter> 100 μm) are essential for cellular infiltration; …
vivo. Macropores (ie, pores with a diameter> 100 μm) are essential for cellular infiltration; …
Subchondral bone-inspired hydrogel scaffold for cartilage regeneration
C Guo, Z Cao, Y Peng, R Wu, H Xu, Z Yuan… - Colloids and Surfaces B …, 2022 - Elsevier
Promoting the in situ regeneration of cartilage without additional cells or cytokines remains
challenging. Here, inspired by the unique microstructures of subchondral bone, a cell and …
challenging. Here, inspired by the unique microstructures of subchondral bone, a cell and …