Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

Genomic imprinting affects a subset of genes in mammals and results in a monoallelic,
parental-specific expression pattern. Most of these genes are located in clusters that are …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

Abstract Background Long non-coding RNAs (lncRNAs) have been implicated in diverse
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far …

Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in
the mouse and human transcriptomes. Two important questions are whether all lncRNAs are …

X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene
expression according to parental origin. It has long been established that imprinted genes …

DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

The identification of the genetic components of autism spectrum disorders (ASDs) has
advanced rapidly in recent years, particularly with the demonstration of de novo mutations …

In autoimmune rheumatic diseases, oestrogens can stimulate certain immune responses
(including effects on B cells and innate immunity), but can also have dose-related anti …