Thrombo-inflammation in acute ischaemic stroke—implications for treatment
G Stoll, B Nieswandt - Nature Reviews Neurology, 2019 - nature.com
Ischaemic stroke elicits a strong neuroinflammatory response, but the functional relevance
and therapeutic potential of neuroinflammation has only recently become apparent. In acute …
and therapeutic potential of neuroinflammation has only recently become apparent. In acute …
[HTML][HTML] Sphingosine-1-phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives
GÁ Bravo, RR Cedeño, MP Casadevall… - Cells, 2022 - mdpi.com
Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules
that are ubiquitously expressed in the human body and play an important role in the immune …
that are ubiquitously expressed in the human body and play an important role in the immune …
[PDF][PDF] Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche
P Codega, V Silva-Vargas, A Paul… - Neuron, 2014 - cell.com
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …
Multiple sclerosis—a quiet revolution
RM Ransohoff, DA Hafler, CF Lucchinetti - Nature Reviews Neurology, 2015 - nature.com
Multiple sclerosis (MS) has been thought to be a complex and indecipherable disease, and
poorly understood with regards to aetiology. Here, we suggest an emphatically positive view …
poorly understood with regards to aetiology. Here, we suggest an emphatically positive view …
[HTML][HTML] A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
L Kappos, EW Radue, P O'Connor… - … England Journal of …, 2010 - Mass Medical Soc
Background Oral fingolimod, a sphingosine-1-phosphate–receptor modulator that prevents
the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end …
the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end …
[HTML][HTML] Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
Background Fingolimod (FTY720), a sphingosine-1-phosphate–receptor modulator that
prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement …
prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement …
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
V Brinkmann, A Billich, T Baumruker… - Nature reviews Drug …, 2010 - nature.com
The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
Neurodegeneration in multiple sclerosis and neuromyelitis optica
I Kawachi, H Lassmann - Journal of Neurology, Neurosurgery & …, 2017 - jnnp.bmj.com
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating
diseases of the central nervous system (CNS), having distinct immunological and …
diseases of the central nervous system (CNS), having distinct immunological and …
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
J Chun, HP Hartung - Clinical neuropharmacology, 2010 - journals.lww.com
Fingolimod (FTY720) is a first-in-class orally bioavailable compound that has shown efficacy
in advanced clinical trials for the treatment of multiple sclerosis (MS). In vivo, fingolimod is …
in advanced clinical trials for the treatment of multiple sclerosis (MS). In vivo, fingolimod is …
A regenerative approach to the treatment of multiple sclerosis
VA Deshmukh, V Tardif, CA Lyssiotis, CC Green… - Nature, 2013 - nature.com
Progressive phases of multiple sclerosis are associated with inhibited differentiation of the
progenitor cell population that generates the mature oligodendrocytes required for …
progenitor cell population that generates the mature oligodendrocytes required for …