Apoptosis-inducing factor (AIF) in physiology and disease: the tale of a repented natural born killer

D Bano, JHM Prehn - EBioMedicine, 2018 - thelancet.com
Apoptosis-inducing factor (AIF) is a mitochondrial oxidoreductase that contributes to cell
death programmes and participates in the assembly of the respiratory chain. Importantly, AIF …

AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases

L Wischhof, E Scifo, D Ehninger, D Bano - EBioMedicine, 2022 - thelancet.com
Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with
diverse functions in cellular physiology. In this regard, a large number of studies have …

Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: a new mechanism involving BAP31 upregulation and MAPK‐ERK pathway

J Zhang, L Wang, W Xie, S Hu, H Zhou… - Journal of cellular …, 2020 - Wiley Online Library
Septic cardiomyopathy is associated with mitochondrial damage and endoplasmic reticulum
(ER) dysfunction. However, the upstream mediator of mitochondrial injury and ER stress has …

[HTML][HTML] Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

T Xin, C Lu - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death.
Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain …

[HTML][HTML] Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: a novel mechanism linking Ripk3-modified mitochondrial performance and …

J Zhong, Y Tan, J Lu, J Liu, X Xiao, P Zhu, S Chen… - Redox biology, 2019 - Elsevier
The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet
been completely clarified. Disease-specific treatments are lacking, and care is still based on …

[HTML][HTML] AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway

C Reinhardt, G Arena, K Nedara, R Edwards… - … et Biophysica Acta (BBA …, 2020 - Elsevier
In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the
optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival …

A metabolism-related gene prognostic index bridging metabolic signatures and antitumor immune cycling in head and neck squamous cell carcinoma

K Du, J Zou, B Wang, C Liu, M Khan, T Xie… - Frontiers in …, 2022 - frontiersin.org
Background In the era of immunotherapy, predictive or prognostic biomarkers for head and
neck squamous cell carcinoma (HNSCC) are urgently needed. Metabolic reprogramming in …

Mitochondrial dynamics related neurovascular approaches in cerebral ischemic injury

H Khan, AK Grewal, TG Singh - Mitochondrion, 2022 - Elsevier
Mitochondria are double-membrane organelles that provide the majority of a cell's energy.
Furthermore, mitochondria are involved in various cellular biological activities, including …

Fatty acid oxidation in immune function

F Kemp, EL Braverman, CA Byersdorfer - Frontiers in immunology, 2024 - frontiersin.org
Cellular metabolism is a crucial determinant of immune cell fate and function. Extensive
studies have demonstrated that metabolic decisions influence immune cell activation …

Renal tubular cell death and inflammation response are regulated by the MAPK-ERK-CREB signaling pathway under hypoxia-reoxygenation injury

Q Dong, Y Jie, J Ma, C Li, T Xin… - Journal of Receptors and …, 2019 - Taylor & Francis
Context: Cell death and inflammation response have been found to the primary features of
acute kidney injury. Objective: The aim of our study is to figure out the molecular mechanism …