Apoptosis-inducing factor (AIF) in physiology and disease: the tale of a repented natural born killer
Apoptosis-inducing factor (AIF) is a mitochondrial oxidoreductase that contributes to cell
death programmes and participates in the assembly of the respiratory chain. Importantly, AIF …
death programmes and participates in the assembly of the respiratory chain. Importantly, AIF …
AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases
Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with
diverse functions in cellular physiology. In this regard, a large number of studies have …
diverse functions in cellular physiology. In this regard, a large number of studies have …
Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: a new mechanism involving BAP31 upregulation and MAPK‐ERK pathway
J Zhang, L Wang, W Xie, S Hu, H Zhou… - Journal of cellular …, 2020 - Wiley Online Library
Septic cardiomyopathy is associated with mitochondrial damage and endoplasmic reticulum
(ER) dysfunction. However, the upstream mediator of mitochondrial injury and ER stress has …
(ER) dysfunction. However, the upstream mediator of mitochondrial injury and ER stress has …
[HTML][HTML] Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction
T Xin, C Lu - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death.
Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain …
Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain …
[HTML][HTML] Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: a novel mechanism linking Ripk3-modified mitochondrial performance and …
J Zhong, Y Tan, J Lu, J Liu, X Xiao, P Zhu, S Chen… - Redox biology, 2019 - Elsevier
The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet
been completely clarified. Disease-specific treatments are lacking, and care is still based on …
been completely clarified. Disease-specific treatments are lacking, and care is still based on …
[HTML][HTML] AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway
C Reinhardt, G Arena, K Nedara, R Edwards… - … et Biophysica Acta (BBA …, 2020 - Elsevier
In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the
optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival …
optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival …
A metabolism-related gene prognostic index bridging metabolic signatures and antitumor immune cycling in head and neck squamous cell carcinoma
Background In the era of immunotherapy, predictive or prognostic biomarkers for head and
neck squamous cell carcinoma (HNSCC) are urgently needed. Metabolic reprogramming in …
neck squamous cell carcinoma (HNSCC) are urgently needed. Metabolic reprogramming in …
Mitochondrial dynamics related neurovascular approaches in cerebral ischemic injury
Mitochondria are double-membrane organelles that provide the majority of a cell's energy.
Furthermore, mitochondria are involved in various cellular biological activities, including …
Furthermore, mitochondria are involved in various cellular biological activities, including …
Fatty acid oxidation in immune function
F Kemp, EL Braverman, CA Byersdorfer - Frontiers in immunology, 2024 - frontiersin.org
Cellular metabolism is a crucial determinant of immune cell fate and function. Extensive
studies have demonstrated that metabolic decisions influence immune cell activation …
studies have demonstrated that metabolic decisions influence immune cell activation …
Renal tubular cell death and inflammation response are regulated by the MAPK-ERK-CREB signaling pathway under hypoxia-reoxygenation injury
Q Dong, Y Jie, J Ma, C Li, T Xin… - Journal of Receptors and …, 2019 - Taylor & Francis
Context: Cell death and inflammation response have been found to the primary features of
acute kidney injury. Objective: The aim of our study is to figure out the molecular mechanism …
acute kidney injury. Objective: The aim of our study is to figure out the molecular mechanism …