Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

A better understanding of the features that define the interaction between cancer cells and
immune cells is important for the development of new cancer therapies. However, focus is …

Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

Cell-free DNA (cfDNA) concentrations from patients with cancer are often elevated
compared with those of healthy controls, but the sources of this extra cfDNA have never …

Neutrophils are becoming recognized as highly versatile and sophisticated cells that display
de novo synthetic capacity and potentially prolonged lifespan. Emerging concepts such as …

Neutrophils are the first responders to inflammation and infection. Recently, an elevated
neutrophil-to-lymphocyte ratio has generally become a prognostic indicator of poor overall …

The engulfment of apoptotic cells by phagocytes, a process referred to as efferocytosis, is
essential for maintenance of normal tissue homeostasis and a prerequisite for the resolution …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …