The CCL5/CCR5 axis in cancer progression
D Aldinucci, C Borghese, N Casagrande - Cancers, 2020 - mdpi.com
Tumor cells can “hijack” chemokine networks to support tumor progression. In this context,
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …
Microglia/brain macrophages as central drivers of brain tumor pathobiology
DH Gutmann, H Kettenmann - Neuron, 2019 - cell.com
One of the most common brain tumors in children and adults is glioma or astrocytoma. There
are few effective therapies for these cancers, and patients with malignant glioma fare poorly …
are few effective therapies for these cancers, and patients with malignant glioma fare poorly …
[HTML][HTML] Mining TCGA database for genes of prognostic value in glioblastoma microenvironment
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The
Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression …
Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression …
CAR T cells for brain tumors: Lessons learned and road ahead
Malignant brain tumors, including glioblastoma, represent some of the most difficult to treat
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …
Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1
C Anastasaki, J Mo, JK Chen, J Chatterjee… - Nature …, 2022 - nature.com
Neuronal activity is emerging as a driver of central and peripheral nervous system cancers.
Here, we examined neuronal physiology in mouse models of the tumor predisposition …
Here, we examined neuronal physiology in mouse models of the tumor predisposition …
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression
Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate
glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells …
glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells …
Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
Brain tumors (gliomas) are heterogeneous cellular ecosystems, where non-neoplastic
monocytic cells have emerged as key regulators of tumor maintenance and progression …
monocytic cells have emerged as key regulators of tumor maintenance and progression …
Microglia/astrocytes–glioblastoma crosstalk: crucial molecular mechanisms and microenvironmental factors
D Matias, J Balça-Silva, GC da Graça… - Frontiers in cellular …, 2018 - frontiersin.org
In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained
prominence in several diseases of the central nervous system, especially in glioblastoma …
prominence in several diseases of the central nervous system, especially in glioblastoma …
CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2
Background Glioma-associated microglia/macrophages (GAMs) comprise macrophages of
peripheral origin and brain-intrinsic microglia, which support tumor progression. Chemokine …
peripheral origin and brain-intrinsic microglia, which support tumor progression. Chemokine …
The role of cytokines and chemokines in shaping the immune microenvironment of glioblastoma: implications for immunotherapy
Glioblastoma is the most common form of primary brain tumour in adults. For more than a
decade, conventional treatment has produced a relatively modest improvement in the …
decade, conventional treatment has produced a relatively modest improvement in the …