Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …
tumors, and these insights have illuminated early detection, risk stratification, prevention …
[HTML][HTML] Telomeres: history, health, and hallmarks of aging
The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …
However, the currently most practicable approaches rely on the generation of DNA double …
Telomeres and telomerase: three decades of progress
JW Shay, WE Wright - Nature Reviews Genetics, 2019 - nature.com
Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …
article highlights the key advances that have expanded our views on the mechanistic …
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …
thus for maintaining genome stability and cellular lifespan. This process requires …
Mechanisms generating cancer genome complexity from a single cell division error
INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …
mutational process, common during tumorigenesis, that results in gene amplification and …
A senescence-centric view of aging: implications for longevity and disease
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
Autophagic cell death restricts chromosomal instability during replicative crisis
J Nassour, R Radford, A Correia, JM Fusté, B Schoell… - Nature, 2019 - nature.com
Replicative crisis is a senescence-independent process that acts as a final barrier against
oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle …
oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle …
53BP1–RIF1–shieldin counteracts DSB resection through CST-and Polα-dependent fill-in
Z Mirman, F Lottersberger, H Takai, T Kibe, Y Gong… - Nature, 2018 - nature.com
In DNA repair, the resection of double-strand breaks dictates the choice between homology-
directed repair—which requires a 3′ overhang—and classical non-homologous end …
directed repair—which requires a 3′ overhang—and classical non-homologous end …
DNA damage and the balance between survival and death in cancer biology
WP Roos, AD Thomas, B Kaina - Nature Reviews Cancer, 2016 - nature.com
DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …