The number of descriptions of emerging viruses has grown at an unprecedented rate since
the beginning of the 21 st century. Severe acute respiratory syndrome coronavirus 2 (SARS …

The type I insulin-like growth factor receptor (IGF-IR) plays multiple roles in several cancers
and increased circulating levels of insulin-like growth factor-I (IGF-I) are associated with …

IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and
oncogenic transformation, as well as tumor growth and metastasis formation in vivo. NVP …

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin.
As carcinomas progress, these tumors may lose epithelial morphology and acquire …

The influx of metastatic tumor cells into the liver triggers a rapid proinflammatory cytokine
cascade. To further analyze this host response, we used intrasplenic/portal inoculation of …

Acromegaly is characterized by sustained elevation of circulating growth hormone (GH) and
insulin-like growth factor I (IGF-I), and is clearly associated with increased morbidity and …

This review examines the rationale for targeting the insulin-like growth factor (IGF)-I receptor
in the therapy of human tumours and their metastases. The rationale is based on two crucial …

In the past three decades, evidence has been accumulating that the IGF-I receptor/ligand
system plays an important role in malignant disease. This has led to a search for specific …

The breakdown of the extracellular matrix (ECM) by proteinases is an essential step in the
process of cancer invasion and metastasis. Malignant progression is frequently associated …