The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

Despite decades of research, cancer metastasis remains an incompletely understood
process that is as complex as it is devastating. In recent years, there has been an increasing …

One hypothesis to explain how mutations in the same nuclear envelope proteins yield
pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners …

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for
which extensive basic knowledge—biochemistry, partners, functions, localizations …

Organization of the genome is critical for maintaining cell-specific gene expression, ensuring
proper cell function. It is well established that the nuclear lamina preferentially associates …

In eukaryotes, the function of the cell's nucleus has primarily been considered to be the
repository for the organism's genome. However, this rather simplistic view is undergoing a …

Mechanical loading induces both nuclear distortion and alterations in gene expression in a
variety of cell types. Mechanotransduction is the process by which extracellular mechanical …