The human gut microbiome is a critical component of digestion, breaking down complex
carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract …

Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

Background Human gut bacteria can synthesize proteinogenic amino acids and produce a
range of metabolites via protein fermentation, some known to exert beneficial or harmful …

The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …

Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …

Many behavioral and psychological symptoms of dementia (BPSD) share similarities in
executive functioning and communication deficits with those described in several …

The histaminergic system (HS) has a critical role in cognition, sleep and other behaviors.
Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many …

Narcolepsy is a life-long, underrecognized sleep disorder that affects 0.02%–0.18% of the
US and Western European populations. Genetic predisposition is suspected because of …

Histaminergic (HA) neurons, found in the posterior hypothalamic tuberomammillary nucleus
(TMN), extend fibers throughout the brain and exert modulatory influence over numerous …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology.
The core syndromes of ASD are deficits in social communication and self-restricted interests …