Ethanol is one of the most commonly abused drugs. Although environmental and genetic
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …

Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on
the brain and behavior. One-dose ethanol exposure induces transient plastic changes in …

Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug-
seeking and drug-taking, loss of control in limiting intake, and the emergence of a …

The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the
global disease burden, contributes substantially to societal and economic costs, and leads …

Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities
globally. Affective disturbances, including stress, depression, and anxiety, are highly …

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalently co-
occurring, important risk factors for a broad array of neuropsychiatric diseases. To date, how …