19F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

I Tirotta, V Dichiarante, C Pigliacelli, G Cavallo… - Chemical …, 2015 - ACS Publications
To enable early monitoring of various diseases, to develop noninvasive diagnostic tools,
and to implement targeted therapies are some of the major challenges in current medicine …

Protein-observed fluorine NMR: a bioorthogonal approach for small molecule discovery: miniperspective

KE Arntson, WCK Pomerantz - Journal of medicinal chemistry, 2016 - ACS Publications
The 19F isotope is 100% naturally abundant and is the second most sensitive and stable
NMR-active nucleus. Unlike the ubiquitous hydrogen atom, fluorine is nearly absent in …

Advanced functional nanomaterials for theranostics

H Huang, JF Lovell - Advanced functional materials, 2017 - Wiley Online Library
Nanoscale materials have been explored extensively as agents for therapeutic and
diagnostic (ie, theranostic) applications. Research efforts have shifted from exploring new …

New frontiers and developing applications in 19F NMR

JX Yu, RR Hallac, S Chiguru, RP Mason - Progress in nuclear magnetic …, 2013 - Elsevier
1.2. Background Fluorine NMR offers many attractive features, most notably detection
sensitivity approaching that of protons. 19 F has a nuclear spin I= 1/2, a gyromagnetic ratio …

[HTML][HTML] The role of imaging biomarkers to guide pharmacological interventions targeting tumor hypoxia

B Gallez - Frontiers in pharmacology, 2022 - frontiersin.org
Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury

E Ansorena, P De Berdt, B Ucakar… - International journal of …, 2013 - Elsevier
We hypothesized that local delivery of GDNF in spinal cord lesion via an injectable alginate
hydrogel gelifying in situ would support spinal cord plasticity and functional recovery. The …

[HTML][HTML] Assessing tumor oxygenation for predicting outcome in radiation oncology: a review of studies correlating tumor hypoxic status and outcome in the preclinical …

F Colliez, B Gallez, BF Jordan - Frontiers in oncology, 2017 - frontiersin.org
Tumor hypoxia is recognized as a limiting factor for the efficacy of radiotherapy, because it
enhances tumor radioresistance. It is strongly suggested that assessing tumor oxygenation …

The need for speed in rodent locomotion analyses

RJ Batka, TJ Brown, KP Mcmillan… - The Anatomical …, 2014 - Wiley Online Library
Locomotion analysis is now widely used across many animal species to understand the
motor defects in disease, functional recovery following neural injury, and the effectiveness of …

[HTML][HTML] Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

R Boursereau, M Abou-Samra, S Lecompte, L Noel… - BMC biology, 2018 - Springer
Abstract Background The hormone adiponectin (ApN) exerts powerful anti-inflammatory
effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular …

[HTML][HTML] DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

EOC Lau, D Damiani, G Chehade, N Ruiz-Reig… - Elife, 2021 - elifesciences.org
Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the
capacity to nucleate and elongate actin filaments and, therefore, to remodel the …