Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
Treatment resistance in psychiatry: state of the art and new directions
OD Howes, ME Thase, T Pillinger - Molecular psychiatry, 2022 - nature.com
Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …
associated with increased healthcare burden and costs up to ten-fold higher relative to …
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
L Sforzini, C Worrell, M Kose, IM Anderson… - Molecular …, 2022 - nature.com
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
Efficacy and safety of fixed-dose esketamine nasal spray combined with a new oral antidepressant in treatment-resistant depression: results of a randomized, double …
M Fedgchin, M Trivedi, EJ Daly… - International Journal …, 2019 - academic.oup.com
Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant …
treatment with multiple antidepressants and are considered to have treatment-resistant …
Depression in the primary care setting
LT Park, CA Zarate Jr - New England Journal of Medicine, 2019 - Mass Medical Soc
Key Clinical Points Depression in the Primary Care Setting Screening for depression and
suicidal thinking and behavior is important in the primary care setting. Distinguishing …
suicidal thinking and behavior is important in the primary care setting. Distinguishing …
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3 …
SH Kennedy, RW Lam, RS McIntyre… - The Canadian …, 2016 - journals.sagepub.com
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …
conducted a revision of the 2009 guidelines by updating the evidence and …
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 4 …
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …
conducted a revision of the 2009 guidelines by updating the evidence and …
[HTML][HTML] Cortico-striatal-thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment
The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …
Postpartum depression
DE Stewart, S Vigod - New England Journal of Medicine, 2016 - Mass Medical Soc
Key Clinical Points Postpartum Depression Postpartum depression is a common, disabling,
and treatable problem that affects the woman, infant, and family. Sensitive inquiry about …
and treatable problem that affects the woman, infant, and family. Sensitive inquiry about …
Postpartum psychiatric disorders
S Meltzer-Brody, LM Howard, V Bergink… - Nature Reviews …, 2018 - nature.com
Pregnancy is a complex and vulnerable period that presents a number of challenges to
women, including the development of postpartum psychiatric disorders (PPDs). These …
women, including the development of postpartum psychiatric disorders (PPDs). These …