Choosing an animal model for the study of Huntington's disease
MA Pouladi, AJ Morton, MR Hayden - Nature Reviews Neuroscience, 2013 - nature.com
Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …
animal models of this disorder have been developed. A frequently asked question is: which …
Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF
S Mitra, H Behbahani, M Eriksdotter - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
S Pun, AF Santos, S Saxena, L Xu, P Caroni - Nature neuroscience, 2006 - nature.com
Neurodegenerative diseases can have long preclinical phases and insidious progression
patterns, but the mechanisms of disease progression are poorly understood. Because …
patterns, but the mechanisms of disease progression are poorly understood. Because …
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants
PA Sieving, RC Caruso, W Tao… - Proceedings of the …, 2006 - National Acad Sciences
Neurotrophic factors are agents with a promising ability to retard progression of
neurodegenerative diseases and are effective in slowing photoreceptor degeneration in …
neurodegenerative diseases and are effective in slowing photoreceptor degeneration in …
Huntington's disease: from pathology and genetics to potential therapies
S Imarisio, J Carmichael, V Korolchuk… - Biochemical …, 2008 - portlandpress.com
Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …
Neurotrophic factors as regenerative therapy for neurodegenerative diseases: current status, challenges and future perspectives
Y El Ouaamari, J Van den Bos, B Willekens… - International journal of …, 2023 - mdpi.com
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic …
Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic …
CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
GCA Elson, E Lelièvre, C Guillet, S Chevalier… - Nature …, 2000 - nature.com
Ciliary neurotrophic factor (CNTF) is a cytokine supporting the differentiation and survival of
various cell types in the peripheral and central nervous systems. Its receptor complex …
various cell types in the peripheral and central nervous systems. Its receptor complex …
Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I …
Huntington's disease (HD) is a monogenic neurodegenerative disease that affects the
efferent neurons of the striatum. The protracted evolution of the pathology over 15 to 20 …
efferent neurons of the striatum. The protracted evolution of the pathology over 15 to 20 …
[图书][B] Intervening in the brain: changing psyche and society
R Merkel, G Boer, J Fegert, T Galert, D Hartmann… - 2007 - Springer
The Europäische Akademie is concerned with the study of the consequences of scientific
and technological advance both for the individual and for society at large as well as for the …
and technological advance both for the individual and for society at large as well as for the …
Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis
H Chen, YC Tung, B Li, K Iqbal, I Grundke-Iqbal - Neurobiology of aging, 2007 - Elsevier
The dentate gyrus of adult mammalian brain contains neural progenitor cells with self-
renewal and multi-lineage potential. The lineage and maturation of the neural progenitors …
renewal and multi-lineage potential. The lineage and maturation of the neural progenitors …