Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Abstract In 2016 the World Health Organization reported 39% of the world's adult population
(over 18 y) was overweight, with western countries such as Australia and the United States …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …

Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …

Impulsive people have a strong urge to act without thinking. It is sometimes regarded as a
positive trait but rash impulsiveness is also widely present in clinical disorders such as …

Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …