Neural circuitry of reward prediction error
M Watabe-Uchida, N Eshel… - Annual review of …, 2017 - annualreviews.org
Dopamine neurons facilitate learning by calculating reward prediction error, or the difference
between expected and actual reward. Despite two decades of research, it remains unclear …
between expected and actual reward. Despite two decades of research, it remains unclear …
[HTML][HTML] The basal ganglia over 500 million years
S Grillner, B Robertson - Current Biology, 2016 - cell.com
The lamprey belongs to the phylogenetically oldest group of vertebrates that diverged from
the mammalian evolutionary line 560 million years ago. A comparison between the lamprey …
the mammalian evolutionary line 560 million years ago. A comparison between the lamprey …
Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons
There is increased appreciation that dopamine neurons in the midbrain respond not only to
reward and reward-predicting cues,, but also to other variables such as the distance to …
reward and reward-predicting cues,, but also to other variables such as the distance to …
Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli
Midbrain dopamine neurons are well known for their role in reward-based reinforcement
learning. We found that the activity of dopamine axons in the posterior tail of the striatum …
learning. We found that the activity of dopamine axons in the posterior tail of the striatum …
[HTML][HTML] A connectome of a learning and memory center in the adult Drosophila brain
Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …
[HTML][HTML] Dopaminergic neurons write and update memories with cell-type-specific rules
Associative learning is thought to involve parallel and distributed mechanisms of memory
formation and storage. In Drosophila, the mushroom body (MB) is the major site of …
formation and storage. In Drosophila, the mushroom body (MB) is the major site of …
[HTML][HTML] Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice
Dopamine neurons are thought to encode novelty in addition to reward prediction error (the
discrepancy between actual and predicted values). In this study, we compared dopamine …
discrepancy between actual and predicted values). In this study, we compared dopamine …
[HTML][HTML] The basal ganglia do not select reach targets but control the urgency of commitment
Prominent theories of decision making suggest that the basal ganglia (BG) play a causal
role in deliberation between action choices. An alternative hypothesis is that deliberation …
role in deliberation between action choices. An alternative hypothesis is that deliberation …
[HTML][HTML] Dopamine circuit mechanisms of addiction-like behaviors
CL Poisson, L Engel, BT Saunders - Frontiers in Neural Circuits, 2021 - frontiersin.org
Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …
addiction is formalized as substance use disorder (SUD), with three primary symptom …
[HTML][HTML] Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task
I Tsutsui-Kimura, H Matsumoto, K Akiti, MM Yamada… - Elife, 2020 - elifesciences.org
Different regions of the striatum regulate different types of behavior. However, how
dopamine signals differ across striatal regions and how dopamine regulates different …
dopamine signals differ across striatal regions and how dopamine regulates different …