Molecular switches of the ADP-ribosylation factor (ARF) GTPase family coordinate
intracellular trafficking at all sorting stations along the secretory pathway, from the ER-Golgi …

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …

Membrane contact sites (MCSs) serve as a zone for nonvesicular lipid transport by oxysterol-
binding protein (OSBP)-related proteins (ORPs). ORPs mediate lipid countertransport, in …

Piezo1 is a recently discovered Ca2+ permeable ion channel that has emerged as an
integral sensor of hemodynamic forces within the cardiovascular system, contributing to …

Lipids must be correctly transported within the cell to the right place at the right time in order
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …

Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

The endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma
membrane (PM) in eukaryotic cells. These ER-PM contact sites play essential roles in lipid …

Extracellular membrane vesicles (EVs) are emerging as new vehicles in intercellular
communication, but how the biological information contained in EVs is shared between cells …

Focal adhesions are multifunctional organelles that couple cell-matrix adhesion to
cytoskeletal force transmission and signaling and to steer cell migration and collective cell …

Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical
forces and regulatory signals between the extracellular matrix and an interacting cell. Two …