The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

The genome is hierarchically organized into several 3D architectures, including chromatin
loops, domains, compartments and regions associated with nuclear lamina and nucleoli …

Neurogenesis comprises many highly regulated processes including proliferation,
differentiation, and maturation. However, the transcriptional landscapes underlying brain …

Antibody affinity maturation occurs in secondary lymphoid organs within germinal centers
(GCs). At these sites, B cells mutate their antibody-encoding genes in the dark zone …

The islets of Langerhans are dynamic structures that can change in size, number of cells,
and molecular function in response to physiological and pathological stress. Molecular cues …

In multiple tissues, stem cell proliferation driving tissue regeneration is dependent on Wnt/β-
catenin signaling, but the identity of the niche cells providing the Wnt proteins is not …

The thermal stability of DNA immobilized on a solid surface is one of the factors that affects
the efficiency of solid-phase amplification (SP-PCR). Although variable temperature …

Objectives Until recently, communication between neighboring cells in islets of Langerhans
was overlooked by genomic technologies, which require rigorous tissue dissociation into …

Abstract Lysinuric Protein Intolerance (LPI) is an inborn error of metabolism resulting from
SLC7A7 deficiency that causes diminished plasma concentration of cationic amino acids …

Detection of nucleic acids within subcellular compartments is key to understanding their
function. Determining the intracellular distribution of nucleic acids requires quantitative …