As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

FILIS KAZAZI-HYSENI, a JOS H. BEIJNEN, a, b JAN HM SCHELLENS a, c aScience Faculty,
Department of Pharmaceutical Sciences, Division of Drug Toxicology, Utrecht University …

Purpose Vascular endothelial growth factor (VEGF) plays an important role in the biology of
ovarian cancer (OC). Inhibitors of VEGF suppress tumor growth in OC models. Metronomic …

Growth of human tumours depends on the supply of oxygen and nutrients via the
surrounding vasculature. Therefore tumour vasculature is an attractive target for anticancer …

Bevacizumab, an anti-vascular endothelial growth factor (VEGF-A) antibody, is used in
metastatic colorectal carcinoma (CRC) treatment, but responses are unpredictable. Vascular …

The 72-kDa type IV collagenase or gelatinase A is the second member of the matrix
metalloproteinase family, MMP-2. Since the discovery of its first two substrates within …

Recognition and management of treatment-related cardiovascular toxicity, defined as either
an acute cardiac event or a chronic condition, has been tightly integrated into routine cancer …

As therapeutic options have multiplied, chemotherapy for metastatic breast cancer (MBC)
has become increasingly complex. Furthermore, advances in the treatment of early-stage …

Objective No standard therapy for advanced adrenocortical carcinoma (ACC) is established
by any randomized trial but a consensus conference 2003 recommended mitotane as …

Tumor neovascularization is a complex process that plays a crucial role in the development
of many different types of cancer. Vascular endothelial growth factor (VEGF) is a potent …