The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

The living cell is an ever changing, responsive, and adaptive environment where proteins
play key roles in all processes and functions. While the scientific community focused for a …

Caspase-1 activation by inflammasome signaling scaffolds initiates inflammation and
antimicrobial responses. Caspase-1 proteolytically converts newly induced pro-interleukin 1 …

Precise control of inflammatory gene expression is critical for effective host defense without
excessive tissue damage. The principal regulator of inflammatory gene expression is …

Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell
survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in …

Degradation tags, otherwise known as degrons, are portable sequences that can be used to
alter protein stability. Here, we report that degron-tagged proteins compete for cellular …

Hydrogen-deuterium exchange mass spectrometry (HDXMS) has emerged as a powerful
approach for revealing folding and allostery in protein-protein interactions. The advent of …

The most commonly inherited dominant ataxia, Spinocerebellar Ataxia Type 3 (SCA3), is
caused by a CAG repeat expansion that encodes an abnormally long polyglutamine (polyQ) …

Stress-response transcription factors such as NFκB turn on hundreds of genes and must
have a mechanism for rapid cessation of transcriptional activation. We recently showed that …

Degrons are short peptide sequences that signalize target sites for protein degradation by
proteases. Herein, we bring forth the discussion on degrons present in proteins related to …