Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …

Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ
and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between …

A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

γδ T cells are unconventional T cells recognizing antigens via their γδ T-cell receptor (TCR)
in a way that is fundamentally different from conventional αβ T cells. γδ T cells usually are …

γδT cells are an unconventional population of T lymphocytes that play an indispensable role
in host defense, immune surveillance, and homeostasis of the immune system. They display …

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset,
recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous …

Simple Summary Research into the immunotherapeutic potential of T cells has
predominantly focused on conventional alpha beta (αβ) T cells, which recognize peptide …

The contributions of γδ T-cells to immunity to infection or tumors critically depend on their
activation and differentiation into effectors capable of secreting cytokines and killing infected …