The treatment of impaired wound healing in diabetes: looking among old drugs

SF Spampinato, GI Caruso, R De Pasquale… - Pharmaceuticals, 2020 - mdpi.com
Chronic wounds often occur in patients with diabetes mellitus due to the impairment of
wound healing. This has negative consequences for both the patient and the medical …

Cellular and molecular processes in wound healing

M Fernández-Guarino, ML Hernández-Bule, S Bacci - Biomedicines, 2023 - mdpi.com
This review summarizes the recent knowledge of the cellular and molecular processes that
occur during wound healing. However, these biological mechanisms have yet to be defined …

Blue-LED-light photobiomodulation of inflammatory responses and new tissue formation in mouse-skin wounds

G Magni, F Tatini, GD Siena, FS Pavone, D Alfieri… - Life, 2022 - mdpi.com
Background: Recent studies evidence that blue-LED-light irradiation can modulate cell
responses in the wound healing process within 24 h from treatment. This study aims to …

Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing

E Seo, JS Lim, JB Jun, W Choi, IS Hong… - Journal of translational …, 2017 - Springer
Background Diminished wound healing is a major complication of diabetes mellitus and can
lead to foot ulcers. However, there are limited therapeutic methods to treat this condition …

Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice

DB Andersen, KV Grunddal, J Pedersen… - …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 receptor (GLP-1R) activation is used in the treatment of
diabetes and obesity; however, GLP-1 induces many other physiological effects with unclear …

Emerging roles of Glucagon like peptide-1 in the management of autoimmune diseases and diabetes-associated comorbidities

S Shao, X Zhang, Q Xu, R Pan, Y Chen - Pharmacology & Therapeutics, 2022 - Elsevier
Currently, gastrointestinal hormone glucagon like peptide-1 (GLP-1) has received significant
attention in maintaining glucose homeostasis through mechanisms involving augmentation …

Blue LED light modulates inflammatory infiltrate and improves the healing of superficial wounds.

G Magni, F Tatini, S Bacci, G Paroli… - Photodermatology …, 2020 - search.ebscohost.com
Our preliminary results indicated that the early activation of cells belonged to a cellular
infiltrate and involved the first phase of wound healing,[7] thus leading to a faster recovery of …

Exenatide inhibits necrosis by enhancing angiogenesis and ameliorating ischemia/reperfusion injury in a random skin flap rat model

JB He, XY Ma, WJ Li, YY Liu, DS Lin - International Immunopharmacology, 2021 - Elsevier
Background Random skin flaps are often used for plastic repair because they are
convenient and flexible. However, necrosis of flaps is a common complication that may lead …

Exendin-4, a glucagon-like peptide-1 analogue, accelerates diabetic wound healing

JN Roan, HN Cheng, CC Young, CJ Lee… - journal of surgical …, 2017 - Elsevier
Background Diabetes disregulates inflammatory responses and impairs vascular function in
wounds. Glucagon-like peptide-1 receptor (Glp-1R) agonists are hypoglycemic agents with …

Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies

F Wang, X Zhang, J Zhang, Q Xu, X Yu… - Medicinal Research …, 2024 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the most costly and serious complications of diabetes.
Treatment of DFU is usually challenging and new approaches are required to improve the …