The histone variant H2A. Z in gene regulation
BD Giaimo, F Ferrante, A Herchenröther, SB Hake… - Epigenetics & …, 2019 - Springer
The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
Histone variants—ancient wrap artists of the epigenome
PB Talbert, S Henikoff - Nature reviews Molecular cell biology, 2010 - nature.com
Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …
Distinct factors control histone variant H3. 3 localization at specific genomic regions
The incorporation of histone H3 variants has been implicated in the epigenetic memory of
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3. 3, we …
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3. 3, we …
Targeting DNA methylation for epigenetic therapy
Patterns of DNA methylation are established during embryonic development and faithfully
copied through somatic cell divisions. Based on current understanding of DNA methylation …
copied through somatic cell divisions. Based on current understanding of DNA methylation …
H3. 3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin
The histone variants H3. 3 and H2A. Z have recently emerged as two of the most important
features in transcriptional regulation, the molecular mechanism of which still remains poorly …
features in transcriptional regulation, the molecular mechanism of which still remains poorly …
LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
T Boulding, RD McCuaig, A Tan, K Hardy, F Wu… - Scientific reports, 2018 - nature.com
Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the
underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is …
underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is …
Acetylation of H2A. Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer
Histone H2A. Z (H2A. Z) is an evolutionarily conserved H2A variant implicated in the
regulation of gene expression; however, its role in transcriptional deregulation in cancer …
regulation of gene expression; however, its role in transcriptional deregulation in cancer …
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation
SS Gehani, S Agrawal-Singh, N Dietrich… - Molecular cell, 2010 - cell.com
Epigenetic regulation of chromatin structure is essential for the expression of genes
determining cellular specification and function. The Polycomb repressive complex 2 (PRC2) …
determining cellular specification and function. The Polycomb repressive complex 2 (PRC2) …
New functions for an old variant: no substitute for histone H3. 3
SJ Elsaesser, AD Goldberg, CD Allis - Current opinion in genetics & …, 2010 - Elsevier
Histone proteins often come in different variants serving specialized functions in addition to
their fundamental role in packaging DNA. The metazoan histone H3. 3 has been most …
their fundamental role in packaging DNA. The metazoan histone H3. 3 has been most …
[HTML][HTML] Histone variants and chromatin structure, update of advances
Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …
functions in the cell: to package the genomic DNA and to regulate gene accessibility …