Cellular mechanisms that regulate the interplay of synaptic excitation and inhibition are
thought to be central to the functional stability of healthy neuronal circuits. A growing body of …

Ubiquitous expression of GABA type A receptors (GABAAR) in the central nervous system
establishes their central role in coordinating most aspects of neural function and …

Preservation of a balance between synaptic excitation and inhibition is critical for normal
brain function. A number of homeostatic cellular mechanisms have been suggested to play a …

Purkinje cells receive synaptic input from several classes of interneurons. Here, we address
the roles of inhibitory molecular layer interneurons in establishing Purkinje cell function in …

Fragile X syndrome (FXS) is a neurodevelopmental disorder, characterized by intellectual
disability and sensory deficits, caused by epigenetic silencing of the FMR1 gene and …

Feedforward excitatory and inhibitory circuits regulate cerebellar output, but how these
circuits interact to shape the somatodendritic excitability of Purkinje cells during motor …

Cholecystokinin (CCK) enables excitatory circuit long-term potentiation (LTP). Here, we
investigated its involvement in the enhancement of inhibitory synapses. Activation of GABA …

The flexibility of neuronal networks is believed to rely mainly on the plasticity of excitatory
synapses. However, like their excitatory counterparts, inhibitory synapses also undergo …

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disease caused
by a polyglutamine expansion in the protein ATXN1, which is involved in transcriptional …

The induction of synaptic plasticity at an individual dendritic glutamatergic spine can affect
neighboring spines. This local modulation generates dendritic plasticity microdomains …