Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …

The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …

In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …

The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing
DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA …

Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic
ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …