Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Mast cells are immune cells which have a widespread distribution in nearly all tissues.
These cells and their mediators are canonically viewed as primary effector cells in allergic …

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …

In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute
IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of …

Stem cell factor (SCF), the ligand of the c-Kit receptor, is expressed by various structural and
inflammatory cells in the airways. Binding of SCF to c-Kit leads to activation of multiple …

Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich.
These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally …

Acute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure
and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI …

Imatinib mesylate (Gleevec), a small molecule inhibitor of abl, kit, and platelet-derived
growth factor receptor (PDGFR) tyrosine kinases, has been reported to be effective in the …

The roles of mast cells in health and disease remain incompletely understood. While the
evidence that mast cells are critical effector cells in IgE-dependent anaphylaxis and other …

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