Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with
high mortality. We used a systematic drug repositioning bioinformatics approach querying a …

A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

The associations of tricyclic antidepressants (TCAs) with reduced incidence of gliomas and
elevated autophagy in glioma cells motivated investigation in mouse models of …

Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a
pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in …

The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

Antidepressant medications are the first-line treatment for people meeting current diagnostic
criteria for major depressive disorder. Most antidepressants are designed to perturb the …

Abstract Mps one binder 2 (MOB2) regulates the NDR kinase family, however, whether and
how it is implicated in cancer remain unknown. Here we show that MOB2 functions as a …

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …