[HTML][HTML] Developments in lung transplantation over the past decade

SC van der Mark, RAS Hoek… - European Respiratory …, 2020 - Eur Respiratory Soc
With an improved median survival of 6.2 years, lung transplantation has become an
increasingly acceptable treatment option for end-stage lung disease. Besides survival …

[HTML][HTML] Ex vivo lung perfusion

T Watanabe, M Cypel, S Keshavjee - Journal of thoracic disease, 2021 - ncbi.nlm.nih.gov
Lung transplantation is a life-saving treatment for patients with end stage lung disease. The
imbalance between lung graft supply and recipients has been a serious issue and barrier to …

Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended …

G Loor, G Warnecke, MA Villavicencio… - The Lancet …, 2019 - thelancet.com
Background Donor lung use for transplantation is the lowest among solid organ tranplants
because of several complex and multifactorial reasons; one area that could have a …

Cytokine absorption during human kidney perfusion reduces delayed graft function–associated inflammatory gene signature

JR Ferdinand, SA Hosgood, T Moore… - American Journal of …, 2021 - Wiley Online Library
Transplantation is the optimal treatment for most patients with end‐stage kidney disease but
organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been …

Ex vivo lung perfusion: a review of current and future application in lung transplantation

K Ahmad, JL Pluhacek, AW Brown - Pulmonary Therapy, 2022 - Springer
The number of waitlisted lung transplant candidates exceeds the availability of donor
organs. Barriers to utilization of donor lungs include suboptimal lung allograft function, long …

In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

[HTML][HTML] The potential of ex vivo lung perfusion on improving organ quality and ameliorating ischemia reperfusion injury

J Iske, CA Hinze, J Salman, A Haverich… - American Journal of …, 2021 - Elsevier
Allogeneic lung transplantation (LuTx) is considered the treatment of choice for a broad
range of advanced, progressive lung diseases resistant to conventional treatment regimens …

Report of the ISHLT Working Group on primary lung graft dysfunction Part IV: Prevention and treatment: A 2016 Consensus Group statement of the International …

D Van Raemdonck, MG Hartwig, MI Hertz… - The Journal of Heart …, 2017 - jhltonline.org
Dysfunction of the pulmonary allograft with impaired oxygenation and radiographic opacities
consistent with pulmonary edema occurs in up to 50% of lung transplant (LTx) recipients. 1 …

REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel …

JR Brede, AK Skulberg, M Rehn, K Thorsen… - Trials, 2021 - Springer
Background Survival after out-of-hospital cardiac arrest (OHCA) is poor and dependent on
high-quality cardiopulmonary resuscitation. Resuscitative endovascular balloon occlusion of …

[HTML][HTML] Outcomes of marginal donors for lung transplantation after ex vivo lung perfusion: a systematic review and meta-analysis

D Tian, Y Wang, H Shiiya, CB Sun, Y Uemura… - The Journal of Thoracic …, 2020 - Elsevier
Objective Ex vivo lung perfusion (EVLP) is reportedly a useful strategy that permits marginal
donor lungs to be evaluated and reconditioned for successful lung transplantation (LTx) …