Flaws in the DNA replication process have emerged as a leading driver of genome
instability in human diseases. Alteration to replication fork progression is a defining feature …

p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent
kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor …

Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding
the structure and dynamics of FAs is critical for designing treatments that overcome plasticity …

Focal copy-number increases (genomic amplification) pinpoint oncogenic driver genes and
therapeutic targets in cancer genomes. With the advent of genomic technologies, recurrent …

In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …

Acute myeloid leukemia (AML) is a myeloid malignancy characterized by the proliferation of
abnormal and immature myeloid blasts in the bone marrow. Circular RNA (circRNA) is a …

Extrachromosomal circular DNA (eccDNA) originates from linear chromosomal DNA in
various human tissues under physiological and disease conditions. The genomic origins of …

DNA replication stress is a major source of DNA damage, including double-stranded breaks
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …

Trypanosoma brucei is a kinetoplastid parasite that causes African trypanosomiasis, which
is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade …

Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin
ligase RAD18 and its downstream effectors, the 'Y-family'Trans-Lesion Synthesis (TLS) DNA …