A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Gut-brain axis: role of lipids in the regulation of inflammation, pain and CNS diseases

R Russo, C Cristiano, C Avagliano… - Current medicinal …, 2018 - ingentaconnect.com
The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

[HTML][HTML] Real life experience of medical cannabis treatment in autism: analysis of safety and efficacy

L Bar-Lev Schleider, R Mechoulam, N Saban, G Meiri… - Scientific reports, 2019 - nature.com
There has been a dramatic increase in the number of children diagnosed with autism
spectrum disorders (ASD) worldwide. Recently anecdotal evidence of possible therapeutic …

Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults …

CM Pretzsch, J Freyberg, B Voinescu… - …, 2019 - nature.com
There is increasing interest in the use of cannabis and its major non-intoxicating component
cannabidiol (CBD) as a treatment for mental health and neurodevelopmental disorders …

Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate …

P Fleury-Teixeira, FV Caixeta… - Frontiers in …, 2019 - frontiersin.org
Autism Spectrum Disorders comprise conditions that may affect cognitive development,
motor skills, social interaction, communication, and behavior. This set of functional deficits …

Plasma anandamide concentrations are lower in children with autism spectrum disorder

DS Karhson, KM Krasinska, JA Dallaire, RA Libove… - Molecular autism, 2018 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder
characterized by restricted, stereotyped behaviors and impairments in social …

Cannabidivarin treatment ameliorates autism-like behaviors and restores hippocampal endocannabinoid system and glia alterations induced by prenatal valproic acid …

E Zamberletti, M Gabaglio… - Frontiers in cellular …, 2019 - frontiersin.org
Autism spectrum disorder (ASD) is a developmental condition whose primary features
include social communication and interaction impairments with restricted or repetitive motor …

The endocannabinoid system and autism spectrum disorders: insights from animal models

E Zamberletti, M Gabaglio, D Parolaro - International journal of molecular …, 2017 - mdpi.com
Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose
symptoms include impaired communication and social interaction with restricted or repetitive …

Sexspecific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling

F Melancia, S Schiavi, M Servadio… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Autism spectrum disorder (ASD) is more commonly diagnosed in
males than in females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is an …

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

V Di Marzo - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-
arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB1 and CB2 …