The role of inflammation in the pathogenesis of preeclampsia

M Michalczyk, A Celewicz, M Celewicz… - Mediators of …, 2020 - Wiley Online Library
Preeclampsia (PE) affects 5‐8% of pregnant women, and it is the major cause of perinatal
morbidity and mortality. It is defined as arterial hypertension in women after 20 weeks of …

Cellular immune responses in the pathophysiology of preeclampsia

D Miller, K Motomura, J Galaz… - Journal of Leukocyte …, 2022 - academic.oup.com
Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum …

SB Cheng, A Nakashima, WJ Huber, S Davis… - Cell death & …, 2019 - nature.com
Systemic manifestation of preeclampsia (PE) is associated with circulating factors, including
inflammatory cytokines and damage-associated molecular patterns (DAMPs), or alarmins …

Inflammasomes: their role in normal and complicated pregnancies

N Gomez-Lopez, K Motomura, D Miller… - The Journal of …, 2019 - journals.aai.org
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia

ML Matias, VJ Gomes, M Romao-Veiga, VR Ribeiro… - Molecules, 2019 - mdpi.com
Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of
cells from the innate immune system. The present study evaluated whether silibinin (SB) …

The NLRP3 inflammasome role in the pathogenesis of pregnancy induced hypertension and preeclampsia

MW Socha, B Malinowski, O Puk, M Dubiel, M Wiciński - Cells, 2020 - mdpi.com
Pregnancy-induced hypertension and preeclampsia are associated with significant maternal
and fetal mortality. A better understanding of these diseases, delineation of molecular …

MiRNA‐548c‐5p downregulates inflammatory response in preeclampsia via targeting PTPRO

Z Wang, P Wang, Z Wang, Z Qin, X Xiu… - Journal of cellular …, 2019 - Wiley Online Library
Preeclampsia is a serious complication of pregnancy and leads to maternal hypertension
and proteinuria. It remains a major health problem for mothers and babies across the world …

Endothelial dysfunction in pregnancy complications

J Kornacki, P Gutaj, A Kalantarova, R Sibiak… - Biomedicines, 2021 - mdpi.com
The endothelium, which constitutes the inner layer of blood vessels and lymphatic
structures, plays an important role in various physiological functions. Alterations in structure …

NLRP3 inflammasome pathway, the hidden balance in pregnancy: A comprehensive review

CN Balci, N Acar - Journal of reproductive immunology, 2024 - Elsevier
The balance of the inflammatory response is indispensable during pregnancy.
Inflammasomes are the cytosolic supramolecular protein complexes activated by pattern …

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women …

ML Matias, M Romao-Veiga, VR Ribeiro… - Journal of Reproductive …, 2021 - Elsevier
This study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD)
on NLRP1/NLRP3 inflammasomes and TLR4/NF-κB pathway in monocytes from pregnant …