Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance

HMA AlSheikh, I Sultan, V Kumar, IA Rather… - Antibiotics, 2020 - mdpi.com
The unprecedented use of antibiotics that led to development of resistance affect human
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …

Nonantibiotic prevention and management of recurrent urinary tract infection

N Sihra, A Goodman, R Zakri, A Sahai… - Nature Reviews …, 2018 - nature.com
Urinary tract infections (UTIs) are highly prevalent, lead to considerable patient morbidity,
incur large financial costs to health-care systems and are one of the most common reasons …

Plant natural products targeting bacterial virulence factors

LN Silva, KR Zimmer, AJ Macedo, DS Trentin - Chemical reviews, 2016 - ACS Publications
Decreased antimicrobial efficiency has become a global public health issue. The paucity of
new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be …

Tackling antibiotic resistance with compounds of natural origin: A comprehensive review

FJ Álvarez-Martínez, E Barrajón-Catalán, V Micol - Biomedicines, 2020 - mdpi.com
Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics
are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are …

Quorum sensing inhibitors: an overview

VC Kalia - Biotechnology advances, 2013 - Elsevier
Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the
emergence of multiple drug resistant strains. Most infectious diseases are caused by …

The Formation of Biofilms by Pseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms

T Rasamiravaka, Q Labtani, P Duez… - BioMed research …, 2015 - Wiley Online Library
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and
chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a …

Quorum sensing inhibitors as anti-biofilm agents

G Brackman, T Coenye - Current pharmaceutical design, 2015 - ingentaconnect.com
Biofilms are microbial sessile communities characterized by cells that are attached to a
substratum or interface or to each other, are embedded in a self-produced matrix of …

Current and recent advanced strategies for combating biofilms

M Sadekuzzaman, S Yang… - … Reviews in Food …, 2015 - Wiley Online Library
Biofilms are matrix‐enclosed microbial aggregates that adhere to a biological or
nonbiological surface. Biofilm formation is a significant problem in the medical, food, and …

Natural products as inspiration for the development of bacterial antibiofilm agents

RJ Melander, AK Basak, C Melander - Natural product reports, 2020 - pubs.rsc.org
Natural products have historically been a rich source of diverse chemical matter with
numerous biological activities, and have played an important role in drug discovery in many …