[HTML][HTML] Noroviruses—the state of the art, nearly fifty years after their initial discovery

LF Ludwig-Begall, A Mauroy, E Thiry - Viruses, 2021 - mdpi.com
Human noroviruses are recognised as the major global cause of viral gastroenteritis. Here,
we provide an overview of notable advances in norovirus research and provide a short …

[HTML][HTML] Favipiravir elicits antiviral mutagenesis during virus replication in vivo

A Arias, L Thorne, I Goodfellow - Elife, 2014 - elifesciences.org
Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral
infections. Several studies have demonstrated that increases in the high mutation rates …

[HTML][HTML] Recent insights into reverse genetics of norovirus

Q Zhang, S Zhu, X Zhang, L Su, J Ni, Y Zhang, L Fang - Virus Research, 2023 - Elsevier
Norovirus is the leading cause of viral gastroenteritis globally, and poses substantial threats
to public health. Despite substantial progress made in preventing norovirus diseases, the …

Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA

K Katayama, K Murakami, TM Sharp… - Proceedings of the …, 2014 - National Acad Sciences
Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. HuNoV
replication studies have been hampered by the inability to grow the virus in cultured cells …

[HTML][HTML] Norovirus translation requires an interaction between the C terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G

L Chung, D Bailey, EN Leen, EP Emmott… - Journal of Biological …, 2014 - ASBMB
Viruses have evolved a variety of mechanisms to usurp the host cell translation machinery to
enable translation of the viral genome in the presence of high levels of cellular mRNAs …

Murine norovirus: additional protocols for basic and antiviral studies

CE Wobus, AM Peiper, AM McSweeney… - Current …, 2023 - Wiley Online Library
Murine norovirus (MNV) is a positive‐sense, plus‐stranded RNA virus in the Caliciviridae
family. Viruses in this family replicate in the intestine and are transmitted by the fecal‐oral …

[HTML][HTML] Molecular and Genetics-Based Systems for Tracing the Evolution and Exploring the Mechanisms of Human Norovirus Infections

SC Lin, GH Bai, PC Lin, CY Chen, YH Hsu… - International journal of …, 2023 - mdpi.com
Human noroviruses (HuNoV) are major causes of acute gastroenteritis around the world.
The high mutation rate and recombination potential of noroviruses are significant challenges …

[HTML][HTML] Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model

MR Herod, O Salim, RJ Skilton, CA Prince, VK Ward… - PloS one, 2014 - journals.plos.org
Investigations into human norovirus infection, replication and pathogenesis, as well as the
development of potential antiviral agents, have been restricted by the lack of a cell culture …

[HTML][HTML] Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity

E Emmott, A de Rougemont, M Hosmillo, J Lu… - Journal of Biological …, 2019 - ASBMB
Norovirus infections are a major cause of acute viral gastroenteritis and a significant burden
on global human health. A vital process for norovirus replication is the processing of the …

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

A Arias, L Thorne, E Ghurburrun, D Bailey… - MSphere, 2016 - Am Soc Microbiol
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus
pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation …