Heavy metals and human health: Possible exposure pathways and the competition for protein binding sites
D Witkowska, J Słowik, K Chilicka - Molecules, 2021 - mdpi.com
Heavy metals enter the human body through the gastrointestinal tract, skin, or via inhalation.
Toxic metals have proven to be a major threat to human health, mostly because of their …
Toxic metals have proven to be a major threat to human health, mostly because of their …
Zinc transporters and their functional integration in mammalian cells
Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …
Manganese regulation of COPII condensation controls circulating lipid homeostasis
X Wang, R Huang, Y Wang, W Zhou, Y Hu, Y Yao… - Nature Cell …, 2023 - nature.com
Precise control of circulating lipids is instrumental in health and disease. Bulk lipids, carried
by specialized lipoproteins, are secreted into the circulation, initially via the coat protein …
by specialized lipoproteins, are secreted into the circulation, initially via the coat protein …
Metal3D: a general deep learning framework for accurate metal ion location prediction in proteins
Metal ions are essential cofactors for many proteins and play a crucial role in many
applications such as enzyme design or design of protein-protein interactions because they …
applications such as enzyme design or design of protein-protein interactions because they …
High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter
Abstract Transporters of the Nramp (Natural resistance-associated macrophage protein)
family import divalent transition metal ions into cells of most organisms. By supporting metal …
family import divalent transition metal ions into cells of most organisms. By supporting metal …
Investigation of the role of TmMYB16/123 and their targets (TmMTP1/11) in the tolerance of Taxus media to cadmium
S Feng, K Hou, H Zhang, C Chen, J Huang… - Tree …, 2023 - academic.oup.com
The toxicity and stress caused by heavy metal contamination has become an important
constraint to the growth and flourishing of trees. In particular, species belonging to the genus …
constraint to the growth and flourishing of trees. In particular, species belonging to the genus …
The effects of the metal ion substitution into the active site of metalloenzymes: A theoretical insight on some selected cases
A large number of enzymes need a metal ion to express their catalytic activity. Among the
different roles that metal ions can play in the catalytic event, the most common are their …
different roles that metal ions can play in the catalytic event, the most common are their …
Zinc homeostasis and regulation: Zinc transmembrane transport through transporters
S Yin, M Duan, B Fang, G Zhao, X Leng… - Critical Reviews in …, 2023 - Taylor & Francis
The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …
performs essential functions in living organisms and bears close relationships with the …
Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence of Staphylococcus aureus
CM Grunenwald, JE Choby, LJ Juttukonda… - MBio, 2019 - Am Soc Microbiol
Manganese (Mn) is an essential micronutrient critical for the pathogenesis of
Staphylococcus aureus, a significant cause of human morbidity and mortality. Paradoxically …
Staphylococcus aureus, a significant cause of human morbidity and mortality. Paradoxically …
[HTML][HTML] Inactivation of RNA and DNA viruses in water by copper and silver ions and their synergistic effect
Cu and Ag have been used as bactericidal agents since ancient times, yet their antiviral
capacity in water remains poorly understood. This study tested the effect of copper (Cu) and …
capacity in water remains poorly understood. This study tested the effect of copper (Cu) and …