IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages

C Chavez, K Lin, A Malveaux, A Gorin, S Brizuela… - Science …, 2025 - science.org
Macrophages exposed to immune stimuli reprogram their epigenomes to alter their
subsequent functions. Exposure to bacterial lipopolysaccharide (LPS) causes widespread …

Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages

S Luecke, X Guo, KM Sheu, A Singh… - Molecular Systems …, 2024 - embopress.org
Macrophages sense pathogens and orchestrate specific immune responses. Stimulus
specificity is thought to be achieved through combinatorial and dynamical coding by …

Integrated metabolomics and network pharmacology approach to exploring the anti-inflammatory mechanisms of Chuanwang xiaoyan capsules

X Meng, C Li, A Gao, H Wang, L Wei, L Sun - Journal of Chromatography B, 2024 - Elsevier
Chuanwang xiaoyan capsules (CWXYC) have anti-inflammatory and detoxification effect,
are used in the treatment of acute and chronic tonsillitis, pharyngitis and other inflammation …

[图书][B] Dissecting the roles of IRFs in de novo enhancer formation in macrophages

C Chavez - 2023 - search.proquest.com
Macrophages exposed to immune stimuli reprogram their epigenomes to alter subsequent
functions. Here, we have dissected the roles of interferon regulatory factors (IRFs) in innate …