Silicosis is an ancient and potentially fatal pneumoconiosis caused by exposure to
respirable crystalline silica. Silicosis is historically a disease of miners; however, failure to …

Inhalation of dust containing crystalline silica is associated with a number of acute and
chronic diseases including systemic autoimmune diseases. Evidence for the link with …

Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause
lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and …

The scavenger receptor cysteine-rich (SRCR) superfamily of soluble or membrane-bound
protein receptors is characterized by the presence of one or several repeats of an ancient …

Silicon dioxide (SiO2) is a mineral compound present in the Earth's crust in two mineral
forms: crystalline and amorphous. Based on epidemiological and/or biological evidence, the …

Environmental exposure to crystalline silica (CS) can lead to silicosis. Alveolar
macrophages (AMs) play a crucial role in the pathogenesis of silicosis. Previously, we …

Macrophage receptor with collagenous structure (MARCO) is a member of the class A
scavenger receptor family which is expressed on the cell surface of macrophages. It is well …

Crystalline forms of silica have been proposed as positive control material for the toxicity test
of inhaled particulate/fibrous matter, although mechanism of silica-induced inhalation toxicity …

Silicosis is a fatal fibrotic lung disease caused by long-term silica particle exposure, in which
pulmonary macrophages play an important role. However, the relationship between …

Alternative activation of alveolar macrophages is linked to fibrosis following exposure to
asbestos. The scavenger receptor, macrophage receptor with collagenous structure …