Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

Repetitive sequences account for more than 50% of the human genome.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease …

▪ Abstract During the development of multicellular organisms, cells become different from
one another by changing their genetic program in response to transient stimuli. Long after …

Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through
many cycles of cell division. Here, we provide evidence for the sequential binding of PcG …

Following fertilization, the genomes of the germ cells are reprogrammed to form the
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …

Polycomb response elements (PREs) are specific cis-regulatory sequences needed for
transcriptional repression of HOX and other target genes by Polycomb group (PcG) proteins …

Propagation of gene-expression patterns through the cell cycle requires the existence of an
epigenetic mark that re-establishes the chromatin architecture of the parental cell in the …

Polycomb group genes (PcG) encode a group of about 16 proteins that were first identified
in Drosophila as repressors of homeotic genes. PcG proteins are present in all metazoans …

Polycomb group (PcG) proteins are essential for accurate axial body patterning during
embryonic development. PcG-mediated repression is conserved in metazoans and is …