Population stratification (PS) is a primary consideration in studies of genetic determinants of
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …

Probabilistic genotyping has become widespread. EuroForMix and DNAStatistX are both
based upon maximum likelihood estimation using a γ model, whereas STRmix™ is a …

DNA evidence is widely used in the modern justice system. Statistical methodology plays a
key role in ensuring that this evidence is collected, interpreted, analysed and presented …

F ST and kinship are key parameters often estimated in modern population genetics studies
in order to quantitatively characterize structure and relatedness. Kinship matrices have also …

Longevity as a complex life-history trait shares an ontogenetic relationship with other
quantitative traits and varies among individuals, families and populations. Heritability …

The interpretation of matching between DNA profiles of a person of interest and an item of
evidence is undertaken using population genetic models to predict the probability of …

In his famous 1972 paper, Richard Lewontin used 'classical'protein-based markers to show
that greater than 85% of human genetic diversity was contained within, rather than between …

Populations are shaped by their history. It is crucial to interpret population structure in an
evolutionary context. Pairwise F ST measures population structure, whereas population …

The two alleles an individual carries at a locus are identical by descent (ibd) if they have
descended from a single ancestral allele in a reference population, and the probability of …

Y chromosome and mitochondrial DNA profiles have been used as evidence in courts for
decades, yet the problem of evaluating the weight of evidence has not been adequately …