Publisher Summary Turns are a fundamental class of polypeptide structure and are defined
as sites where the peptide chain reverses its overall direction. In the past 20 years, the …

Abstract 2D NMR is extensively used in many different fields, and its potential for the study of
complex biochemical or chemical mixtures has been widely demonstrated. 2D NMR gives …

A two-dimensional (2D) correlation method generally applicable to various types of
spectroscopy, including IR and Raman spectroscopy, is introduced. In the proposed 2D …

The rate of exchange of peptide group NH hydrogens with the hydrogens of aqueous
solvent is sensitive to neighboring side chains. To evaluate the effects of protein side chains …

Recently, we have shown that net magnetization transfer among scalar coupled
homonuclear spins can be obtained by the application of a spin-lock field (I), or more …

A novel concept in vibrational spectroscopy called two-dimensional infrared (2D IR)
spectroscopy is described. In 2D IR, a spectrum defined by two independent wavenumbers …

High-resolution 750 MHz 1H NMR spectra of control human blood plasma have been
measured and assigned by the concerted use of a range of spin-echo, two-dimensional J …

Halichondrins—antitumor polyether macrolides Page 1 Pure & App!. Chem., Vol. 58, No. 5,
pp. 701—710, 1986. Printed in Great Britain. © 1986 IUPAC Halichondrins—antitumor …

= Ph), when hydrolyzed under the above conditions, afforded a quantitative yield of (25)-
azidophenylacetic acid (6d)(R= Ph) having a minimum enantiomeric purity of 99.5%. In the …

Two-dimensional correlated spectroscopy (COSY) is used for measurements of proton-
proton spin-spin coupling constants in protein 1 H NMR spectra. High digital resolution …