Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …

Phosphatidylinositol 3‐kinase (PI3K) regulates several vital cellular processes, including
signal transduction and membrane trafficking. In order to study the intracellular localization …

AP2 is the best-characterized member of the family of heterotetrameric clathrin adaptor
complexes that play pivotal roles in many vesicle trafficking pathways within the cell. AP2 …

The movement of lipids within and between intracellular membranes is mediated by different
lipid transport mechanisms and is crucial for maintaining the identities of different cellular …

Background Phosphoinositides are required for the recruitment of many proteins to both the
plasma membrane and the endosome; however, their role in protein targeting to other …

Cholesterol is dynamically transported among membrane-bound organelles primarily by
nonvesicular mechanisms. Sterol transfer proteins (STPs) bind cholesterol in their …

PH (pleckstrin homology) domains represent the 11th most common domain in the human
proteome. They are best known for their ability to bind phosphoinositides with high affinity …