A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Polyunsaturated fatty acids (PUFAs) and their metabolites have a variety of physiological
roles including: energy provision, membrane structure, cell signaling and regulation of gene …

α-Synuclein (αSyn) aggregation and mitochondrial dysfunction both contribute to the
pathogenesis of Parkinson disease (PD). Although recent studies have suggested that …

Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar
glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Age has a powerful effect on enhanced susceptibility to neurodegenerative diseases,
including susceptibility to stroke and cognitive impairment (CI) even in optimally healthy …

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular
and cellular dysfunction that plays a major role in ageing and most age-related and …

There is increasing evidence that aldehydes generated endogenously during the
degradation process of biological molecules are involved in many of the pathophysiologies …

A strong water-soluble antioxidant was identified in the popular commercial banana Musa
cavendishii. It is dopamine, one of the catecholamines. For suppressing the oxygen uptake …

Mitochondria are intimately involved in the generation of and defense against reactive
oxygen species (ROS). Mitochondria are themselves targets of oxidative stress and also …