Emerging concepts of epigenetic dysregulation in hematological malignancies
P Ntziachristos, O Abdel-Wahab, I Aifantis - Nature immunology, 2016 - nature.com
The past decade brought a revolution in understanding of the structure, topology and
disease-inducing lesions of RNA and DNA, fueled by unprecedented progress in next …
disease-inducing lesions of RNA and DNA, fueled by unprecedented progress in next …
Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms
9p21 locus is one of the most reproducible regions in genome-wide association studies
(GWAS). The region harbors CDKN2A/B genes that code for p16INK4a, p15INK4b, and …
(GWAS). The region harbors CDKN2A/B genes that code for p16INK4a, p15INK4b, and …
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development
Memory B cells (MBCs) are essential for long-lived humoral immunity. However, the
transcription factors involved in MBC differentiation are poorly defined. Here, using single …
transcription factors involved in MBC differentiation are poorly defined. Here, using single …
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation
Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and
clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes …
clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes …
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
Formation of the lymphatic system requires the coordinated expression of several key
regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key …
regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key …
High expression of CPT1A predicts adverse outcomes: a potential therapeutic target for acute myeloid leukemia
Carnitine palmitoyl transferase 1A (CPT1A) protein catalyzes the rate-limiting step of Fatty-
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
DNA methylation, which is modulated by both genetic factors and environmental exposures,
may offer a unique opportunity to discover novel biomarkers of disease-related brain …
may offer a unique opportunity to discover novel biomarkers of disease-related brain …
EVI1 drives leukemogenesis through aberrant ERG activation
J Schmoellerl, IAM Barbosa, M Minnich, F Andersch… - Blood, 2023 - ashpublications.org
Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …
The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease
The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional
repressor that is of fundamental importance across species, as evident by its evolutionary …
repressor that is of fundamental importance across species, as evident by its evolutionary …
RUNX1 cooperates with FLT3-ITD to induce leukemia
K Behrens, K Maul, N Tekin, N Kriebitzsch… - Journal of Experimental …, 2017 - rupress.org
Acute myeloid leukemia (AML) is induced by the cooperative action of deregulated genes
that perturb self-renewal, proliferation, and differentiation. Internal tandem duplications …
that perturb self-renewal, proliferation, and differentiation. Internal tandem duplications …