Breast cancer is one of the most common cancers in women around the globe Tamoxifen is
used for the last 40 years as an endocrine therapy for breast cancer. This resulted in the …

Antiestrogens include agents such as tamoxifen, toremifene, raloxifene, and fulvestrant.
Currently, tamoxifen is the only drug approved for use in breast cancer chemoprevention …

Cancer chemopreventive agents are typically natural products or their synthetic analogs that
inhibit the transformation of normal cells to premalignant cells or the progression of …

Mitogen-activated protein kinase (MAP kinase) cascades transmit and amplify signals
involved in cell proliferation as well as cell death. These signal transduction pathways serve …

Antiestrogen therapy remains one of the most widely used and effective treatments for the
management of endocrine responsive breast cancers. This reflects the ability of …

3, 3′-Diindolylmethane (DIM) is a major invivo derivative of the putative anticancer agent
indole-3-carbinol (I3C), which is present in vegetables of the Brassica genus. At …

Objective (s): This study focused on determining cytotoxic effects of copper oxide
nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific …

The mitogenic effect of 17β-estradiol (E2) on the breast is mediated by estrogen receptor
alfa (ERα), hence ERα antagonists are effective in the treatment of breast cancer. The …

Breast tumors expressing estrogen receptor-α (ER) respond well to therapeutic strategies
using selective ER modulators, such as tamoxifen. However,∼ 30% of invasive breast …

Tamoxifen is the most commonly prescribed therapy for patients with estrogen receptor (ER)
α-positive breast tumors. Tumor resistance to tamoxifen remains a serious clinical problem …