DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
DNA methylation and regulation of gene expression: Guardian of our health
GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
Smoking changes adaptive immunity with persistent effects
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
Evaluation of DNA methylation episignatures for diagnosis and phenotype correlations in 42 Mendelian neurodevelopmental disorders
E Aref-Eshghi, J Kerkhof, VP Pedro… - The American Journal of …, 2020 - cell.com
Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …
ambiguous genetic findings which can confound accurate diagnosis and clinical …
Diagnostic utility of genome-wide DNA methylation testing in genetically unsolved individuals with suspected hereditary conditions
E Aref-Eshghi, EG Bend, S Colaiacovo… - The American Journal of …, 2019 - cell.com
Conventional genetic testing of individuals with neurodevelopmental presentations and
congenital anomalies (ND/CAs), ie, the analysis of sequence and copy number variants …
congenital anomalies (ND/CAs), ie, the analysis of sequence and copy number variants …
Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection
AK Hedström - Frontiers in Immunology, 2023 - frontiersin.org
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …
disease and diabetes. Many smoking-associated signals have been detected in the blood …
Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with …
Background: Several studies have shown effects of current and maternal smoking during
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
Determinants of serum immunoglobulin levels: a systematic review and meta-analysis
SR Khan, AC van der Burgh, RP Peeters… - Frontiers in …, 2021 - frontiersin.org
Background An up-to-date overview of determinants of serum immunoglobulins in adults is
pivotal for clinical practice and research, but currently lacking. We therefore performed a …
pivotal for clinical practice and research, but currently lacking. We therefore performed a …
A systematic review of smoking-related epigenetic alterations
The aim of this study is to provide a systematic review of the known epigenetic alterations
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …