The inability to repair DNA damage properly in mammals leads to various disorders and
enhanced rates of tumour development. Organisms respond to chromosomal insults by …

This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

Mammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric
repeat–binding factors TRF1 and TRF2. Inhibition of TRF2 results in immediate deprotection …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …

Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions
at the ends of macronuclear chromosomes. We have now identified homologous proteins in …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase
that is activated upon association with DNA. Biochemical and genetic data have revealed …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …