Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

S Hunt, Y Leibner, EJ Mertens, N Barros-Zulaica… - Cerebral …, 2023 - academic.oup.com
Synaptic transmission constitutes the primary mode of communication between neurons. It is
extensively studied in rodent but not human neocortex. We characterized synaptic …

Multiscale network neuroscience in neuro-oncology: How tumors, brain networks, and behavior connect across scales

DA Maas, L Douw - Neuro-Oncology Practice, 2023 - academic.oup.com
Network neuroscience refers to the investigation of brain networks across different spatial
and temporal scales, and has become a leading framework to understand the biology and …

Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types

SLW Driessens, AA Galakhova, DB Heyer… - Nature …, 2023 - nature.com
GWAS have identified numerous genes associated with human cognition but their cell type
expression profiles in the human brain are unknown. These genes overlap with human …

Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling

R Wilbers, VD Metodieva, S Duverdin, DB Heyer… - Science …, 2023 - science.org
Human cortical pyramidal neurons are large, have extensive dendritic trees, and yet have
unexpectedly fast input-output properties: Rapid subthreshold synaptic membrane potential …

[PDF][PDF] Large and fast excitatory transcriptomic neuron types in human cortex preferentially express genes of intelligence and HARs.

S Driessens, D Heyer, I Pieterse, R Wilbers, E Mertens… - 2022 - scholar.archive.org
Human intelligence is a highly heritable trait, and GWAS have yielded numerous associated
genes. These genes overlap with human accelerated regions (HARs) implicated in human …