Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Biomedicine meets Fenton chemistry

Z Tang, P Zhao, H Wang, Y Liu, W Bu - Chemical reviews, 2021 - ACS Publications
Since the first connection between Fenton chemistry and biomedicine, numerous studies
have been presented in this field. Comprehensive presentation of the guidance from Fenton …

An enzyme‐engineered nonporous copper (I) coordination polymer nanoplatform for cuproptosis‐based synergistic cancer therapy

Y Xu, SY Liu, L Zeng, H Ma, Y Zhang… - Advanced …, 2022 - Wiley Online Library
Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers
great opportunities for exploring the use of copper‐based nanomaterials inducing …

A polymeric hydrogel to eliminate programmed death-ligand 1 for enhanced tumor radio-immunotherapy

W Shen, P Pei, C Zhang, J Li, X Han, T Liu, X Shi… - ACS …, 2023 - ACS Publications
Programmed death-ligand 1 (PD-L1) is a specialized shield on tumor cells that evades the
immune system. Even inhibited by PD-L1 antibodies, a cycling process constantly transports …

Role of LDH in tumor glycolysis: regulation of LDHA by small molecules for cancer therapeutics

D Sharma, M Singh, R Rani - Seminars in cancer biology, 2022 - Elsevier
Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

Chemical design of activatable photoacoustic probes for precise biomedical applications

Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism

I Elia, MC Haigis - Nature metabolism, 2021 - nature.com
Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis

BM Henry, G Aggarwal, J Wong, S Benoit… - The American journal of …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic
state, affecting more than a million patients worldwide. Predictors of disease outcomes in …